About Us
MPSlabs is a dedicated business unit of ESQlabs. Our international and multidisciplinary team develops software solutions and provides consulting services for pharmaceutical companies and research institutions working in the field of microphysiological systems and organ-on-chips.
At MPSlabs, our mission is to enhance the predictive power of MPS and OoCs in drug testing. Through our advanced platforms, we facilitate the emulation of human physiological conditions within these systems and translate the results to in-human situations more accurately, assessing drug efficacy, and identifying potential hazards earlier.
Services
We provide a wide range of simulation services for MPS systems to support end-users in MPS operations and facilitate their decision-making process.
Pillar I – Multi-functional Scaling
Our expertise in microphysiological systems (MPS) and organ-on-chips (OoCs) allows us to optimize the morphology and geometry of these systems for more accurate replication of human physiology in vitro.
Pillar II – Experimental Design and Operation
We offer tailored protocol design services for a wide range of MPS systems, allowing researchers to set up experiments with precision and confidence. Our protocols are designed to simulate operating scenarios and model complex biological processes, providing researchers with valuable insights into drug behavior and efficacy.
Pillar III – Integration into ESQlabs Core
Our integration services seamlessly incorporate MPS and OoC data into the core services of ESQlabs, enhancing translational and predictive accuracy throughout the drug development process. By predicting in vivo dose exposure, simulating drug-drug interaction scenarios, and accounting for special populations, we empower researchers to make informed decisions and accelerate the path to clinical success.
Our Pipeline
Projects
German:
MPS-Simulator ist ein Großvorhaben, in dem wir Leber- und Darm-Chips digital abbilden und ihre Daten in in-silico-PBPK-Modelle einspeisen. Dadurch lassen sich Clearance, Exposition und DILI-Risiko von über 30 Arzneistoffen schon im Labor präzise abschätzen. Fünf Showcase-Verbindungen dienen zur strengen Validierung der Software, die als benutzerfreundliche Cloud-App erscheint. ESQlabs arbeitet bis April 2028 an dieser wegweisenden Alternative zu Tierversuchen.
Dieses Projekt wird durch den Europäischen Fonds für regionale Entwicklung (EFRE) und das Land Niedersachsen im Rahmen „Europa für Niedersachsen“ 2021-2027 kofinanziert.
English:
MPS Simulator is a flagship project that digitises liver- and gut-on-chip systems, feeding their outputs into in-silico PBPK models. This lets us predict clearance, exposure and DILI risk for 30+ drugs, with five showcase compounds reserved for rigorous validation. The result will be an easy-to-use cloud app, delivered by ESQlabs until April 2028.
The project is co-funded by the European Regional Development Fund (ERDF) and the State of Lower Saxony under the “Europe for Lower Saxony” 2021-2027 programme.
News
Team
