Our Systems Toxicology Team had a Blast at ICT2022!

The scientific work was a team effort and resulted in two posters and an oral presentation:

A Poster by Huan Yang (P04-05): Machine-learning aided multi-scale modeling framework for toxicological endpoint predictions in the dog (-> Link)
-> Dr. H. Yang won the AstraZeneca early career award for this work, congrats!

A Poster by Vanessa Baier (P17-13): Development and application of a generic avian physiologically based kinetic (PBK) model for three bird species (-> Link; -> Paper Preprint; -> Model Files (soon to be uploaded))

A Talk by Alicia Paini (S28-03): Using adverse outcome pathways (AOPs) to support tiered-testing strategies for toxicity assessment.

We thank our collaborators (Bayer, EPAA, LJMU) and the EU-funded ONTOX project. Also, our PhD student Rene Geci (S28-01, P04-05), and our CEO Stephan Schaller for their contributions and support!

Further content the team contributed to, were:

• S28-01: Characterising applicability domains of generic in vitro distribution kinetic and physiologically based kinetic models
• P01-07: Development of an adverse outcome pathway for kidney tubular necrosis
• P04-23: A knowledge hub leveraging public resources to improve in silico chemical safety assessment
• P17-04: An automated tool for selection of chemical analogues to facilitate development of new physiologically-based kinetic models using a read-across approach
• P21-31: Criteria for selecting physiologically-based kinetic models for use in developing new models for data-poor analogues via a read across approach

The esqLABS Team is very much looking forward to EUROTOX2023, where esqLABS will participate with a strong lineup!

See you next year in Ljubljana, Slovenia!