2-Day OSP Suite Workshop
esqLABS is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland in Baltimore, MD.
PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP
esqLABS, in collaboration with the University of Maryland, is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland (Pharmacy Hall, 20 N Pine St, Baltimore, MD 21201). The workshop covers the basics of PBPK and concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:
- Build a PBPK model in PK-Sim and compare to observed data
- Learn how to consider age-dependency in drug PK in PK-Sim (Pediatrics and Geriatrics)
- Conduct population simulations in PK-Sim and MoBi
- Learn how to model drug-drug interactions in PK-Sim (DDI)
- Integrate mechanism-based pharmacodynamics in MoBi
- Conduct parameter identifications in PK-Sim and MoBi
- Simulate and analyze your PB-QSP model in R
This workshop will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.
While the workshop does not require any prior experience with PK-Sim® & MoBi®, most topics will be of interest even for advanced users.
To register for the workshop, please visit EventBrite.
The workshop is currently restricted to 15 participants.
Registration includes coffee- and lunch breaks.
As use-cases for above learnings, we will develop PBPK models for small molecules and biologics and a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:
|Time (Saturday March 16)||Topic|
|9:00||Welcome and getting everyone started (solving IT issues)|
|9:30||Lecture: Introduction to PBPK modeling and the OSP Suite (PK-Sim® & MoBi®)|
|10:00||Hands-On: Setting up a simple PBPK model|
|11:00||Lecture: General concepts of PBPK modeling|
|11:30||Lecture: PBPK for drug-drug interactions (DDI) with PK-Sim®|
|13:00||Hands-On: Modeling drug-drug interactions (DDI) with PK-Sim®|
|14:45||Lecture: Special populations – pediatrics and elderly|
|15:30||Hands-On: Age Dependence of Pharmacokinetics (Population Simulations)|
|16:30||Wrap-up and Q & A|
|Time (Sunday March 17)||Topic|
|9:00||Welcome and getting everyone started (follow-up Day 1)|
|9:15||Lecture: Introduction to MoBi®|
|9:30||Hands-On: Building an ADC PBPK model|
|10:15||Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition|
|11:15||Hands-On: Tumor growth modeling|
|13:00||Lecture: Parameter Identification using PK-Sim® and Mobi®|
|13:30||Hands-On: Parameter Identification|
|14:15||Hands-On: nAb / ADC tumor treatment (PD-Effect)|
|15:45||Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R|
|16:30||Wrap-up and Q & A|
- To download the software, please click here
- Download & install the R distribution (Ver 3.5) from here
- Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
- For starters, please check out the OSP tutorial site (videos & hands-on) here
Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.
(Managing Director, esqLABS GmbH)