2-Day OSP Suite Workshop

esqLABS is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland in Baltimore, MD.

PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP

 

esqLABS, in collaboration with the University of Maryland, is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland (Pharmacy Hall, 20 N Pine St, Baltimore, MD 21201). The workshop covers the basics of PBPK and concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Learn how to consider age-dependency in drug PK in PK-Sim (Pediatrics and Geriatrics)
  •  Conduct population simulations in PK-Sim and MoBi
  • Learn how to model drug-drug interactions in PK-Sim (DDI)
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  •  Simulate and analyze your PB-QSP model in R

This workshop will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, most topics will be of interest even for advanced users.

REGISTRATION

To register for the workshop, please visit EventBrite.

The workshop is currently restricted to 15 participants.

Registration includes coffee- and lunch breaks.

AGENDA

As use-cases for above learnings, we will develop PBPK models for small molecules and biologics and a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Day 1

Time (Saturday March 16) Topic
9:00 Welcome and getting everyone started (solving IT issues)
9:30 Lecture: Introduction to PBPK modeling and the OSP Suite (PK-Sim® & MoBi®)
10:00 Hands-On: Setting up a simple PBPK model
10:45 Coffee Break
11:00 Lecture: General concepts of PBPK modeling
11:30 Lecture: PBPK for drug-drug interactions (DDI) with PK-Sim®
12:00 Lunch Break
13:00 Hands-On: Modeling drug-drug interactions (DDI) with PK-Sim®
14:45 Lecture: Special populations – pediatrics and elderly
15:15 Coffee Break
15:30 Hands-On: Age Dependence of Pharmacokinetics (Population Simulations)
16:30 Wrap-up and Q & A
17:00 END

Day 2

Time (Sunday March 17) Topic
9:00 Welcome and getting everyone started (follow-up Day 1)
9:15 Lecture: Introduction to MoBi®
9:30 Hands-On: Building an ADC PBPK model
10:00 Coffee Break
10:15 Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition
11:15 Hands-On: Tumor growth modeling
12:00 Lunch Break
13:00 Lecture: Parameter Identification using PK-Sim® and Mobi®
13:30 Hands-On: Parameter Identification
14:00 Coffee Break
14:15 Hands-On: nAb / ADC tumor treatment (PD-Effect)
15:45 Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R
16:30 Wrap-up and Q & A
17:00 END

PREPARATION

  • To download the software, please click here
  • Download & install the R distribution (Ver 3.5) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the OSP tutorial site (videos & hands-on) here

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.

Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

Get in touch now

Contact

esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com