2-Day OSPS Workshop in BOSTON October 2018

esqLABS is running a two-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP on Wednesday 3rd and Thursday 4th of October at the OFICIO Fenway Meeting Room in Boston, MA.

PK-Sim® & MoBi® workshop on integrating PBPK with QSP for Biologics

 

esqLABS is running a two-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP on Wednesday and Thursday 3rd and 4th of October at the OFICIO Fenway Meeting Room in Boston, MA. The workshop covers the concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  •  Conduct population simulations in PK-Sim and MoBi
  •  Scale PB-QSP models across species
  •  Simulate and analyze your PB-QSP model in R

This workshop will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, most topics will be of interest even for advanced users.

REGISTRATION

For more information and registration, please visit EventBrite.

The workshop is currently restricted to 15 participants.

 

AGENDA

As a use-case for above learnings, we will develop a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Day 1

Time (Wednesday October 3) Topic
9:00 Welcome and getting everyone started (solving IT issues)
9:45 Lecture: Introduction to PBPK modeling
10:30 Hands-On (with Intro): Building a nAb / ADC PBPK model
11:00 Coffee Break
11:15 Lecture: General concepts of PBPK modeling
11:45 Lecture: Introduction to MoBi
12:15 Lunch Break (NOT INCLUDED! Will go for lunch at a restaurant nearby)
13:15 Hands-On (with Intro): Introduction to mechanistic modeling with MoBi: target-mediated drug disposition
15:00 Coffee Break
15:15 Hands-On (with Intro): Population Simulations
16:00 Lecture: Complex PB-QSP models: The Diabetes Platform
16:30 Wrap-up and Q & A
17:00 END

Day 2

Time (Thursday October 4) Topic
9:00 Welcome and getting everyone started (follow-up Day 1)
9:15 Hands-On (with Intro): Model extension: Tumor
11:00 Coffee Break
11:15 Hands-On (with Intro): Creating reactions & Tumor growth modeling
12:00 Lunch Break (NOT INCLUDED! Will go for lunch at a restaurant nearby)
13:00 Lecture & Hands-on: Parameter Identification using PK-Sim® and Mobi®
13:30 Hands-On (with Intro): nAb / ADC tumor treatment (PD-Effect)
15:00 Coffee Break
15:15 Hands-On (with Intro): Running simulations with the OSPS R-Toolbox in R
16:30 Wrap-up and Q & A
17:00 END


PREPARATION

  • To download the software, please click here
  • Download & install the R distribution (Ver 3.5) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the OSP tutorial site (videos & hands-on) here

 

Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

Get in touch now

Contact

esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com