OSPS Workshop @ ACoP 2018
esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP on Saturday October 6, 2018 at the Loews Coronado Bay Resort near San Diego, CA, United States.
PK-Sim® & MoBi® workshop on integrating PBPK with QSP
esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP on Saturday October 6, 2018 at the Loews Coronado Bay Resort near San Diego, CA, United States (For details on the workshop venue see ACoP9 registration site). The workshop covers the concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:
- Build a PBPK model in PK-Sim and compare to observed data
- Integrate mechanism-based pharmacodynamics in MoBi
- Simulate and analyze your PBPK-QSP model in R
This workshop will be held by consultants & scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.
While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.
Cost: 700 USD. We offer a reduced price of 350 USD for academics & non-profit organization employees to cover breakfast, lunch and coffee breaks.
NOTICE: due to popular demand, registration for ACoP9 is FULL. Registration for ACoP9 is closed!!
TO REGISTER FOR THE WORKSHOP, PLEASE WRITE AN EMAIL TO: firstname.lastname@example.org !
The workshop is currently restricted to 40 participants.
As a use-case for above learnings, we will develop a PB-QSP model for naked antibody (nAb) pre-treatment for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:
|Time (Saturday, October 6th)||Topic|
|8:00||Welcome and getting everyone started (solving IT issues)|
|8:30||Lecture: Introduction to PBPK modeling|
|9:00||Hands-On (with Intro): Building a nAb / ADC PBPK model|
|10:15||Lecture: General concepts of PBPK modeling|
|10:45||Lecture: Introduction to MoBi|
|11:15||Demo: Introduction to mechanistic modeling with MoBi: target-mediated drug disposition|
|13:00||Hands-On (with Intro): Model extension: Tumor|
|13:30||Hands-On (with Intro): Creating reactions|
|14:00||Hands-On (with Intro): Tumor growth modeling|
|14:30||Hands-On (with Intro): nAb / ADC tumor treatment (PD-Effect)|
|15:15||Hands-On (with Intro): Running (parallel) simulations with the OSPS R-Toolbox in R|
|16:00||Lecture: Complex PB-QSP models: The Diabetes Platform|
|16:30||Wrap-up and Q & A|
- To download the software, please click here
- Download & install the R distribution from here
- Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
- For starters, please check out the OSP tutorial site (videos & hands-on) here
- All registered participants will be informed by email of any changes.
(Managing Director, esqLABS GmbH)