open position:

Scientific Director PBPK (m/f)

Full Time, Starts immediately (January 1, 2020; Home Office based (EU-wide, with good connectivity to Frankfurt, Germany))

Scientific Director PBPK (m/f)

esqLABS has exciting projects for a highly talented and motivated life-science modeling & simulation scientist who enjoys driving innovations and setting new boundaries in physiologically-based (PBPK) modeling, pharmacometrics, & quantitative systems pharmacology (QSP).

esqLABS is not only an innovative contract research organization for the pharmaceutical, chemical, and food industry specialized in PBPK and QSP, but also a member of the Open-Systems-Pharmacology (OSP) Management Team. We help drive the development and standards of the open domain software (PK-Sim® and MoBi®) within a cross-functional environment with academia and industry to push the boundaries of quantitative systems pharmacology and systems toxicology. esqLABS has gained considerable momentum, providing world-wide services and attracting international players in the pharma and crop industry but also start-ups in the life-science technology sector as clients. In addition, funding through national and EU-wide research grants allows us to progressively further the development of our core technologies.

To help us grow and lead our global PBPK business, we are looking for a Scientific Director for PBPK (m/f) to strengthen our team.

About your new role

Are you a highly talented and motivated life-science modeling & simulation scientist? Do you enjoy driving innovation and setting new boundaries in physiologically-based (PBPK) modeling, pharmacometrics, & quantitative systems pharmacology (QSP)? Then this could be a good fit:

  • Scientific lead for our PBPK Business & Strategy development
  • Project management for client projects in our PBPK business
  • Assess and define regulatory requirements and compile submission-ready reports
  • Support customer projects (Hands-on PBPK model development)
  • Track use cases and communicate with peers to assess project requirements
  • Challenge (project) requirements and engineer feasible solutions from start till end

Skills & experience we require

  • 5+ years of experience in applications of PBPK modeling in pre-clinical and clinical development
  • 5+ years of experience in leading modeling & simulation projects for clients
  • Advanced expertise in domain-specific modeling software (e.g. PK-Sim® / MoBi®, SimCyp®, or GastroPlus®)
  • Profound knowledge of the drug discovery and development process
  • Profound knowledge of regulatory requirements and guidelines for PBPK and PD
  • Experience in (IND/NDA) submissions
  • Fluency in English (oral and written)

Skills & experience that are nice to have

  • Advanced expertise in pharmacometric modeling software (e.g. NONMEM®, Monolix, or IQRtools)
  • Proficiency in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)
  • A strong understanding of statistics
  • Therapeutic domain knowledge: Diabetes, Oncology, Immunology or Inflammation
  • Published peer-reviewed articles

What we offer

  • A passionate and dedicated team with people who are always willing to broaden their horizon
  • Flexible work hours and a home office policy that focuses on people and not on numbers
  • An attractive remuneration package
  • A dedicated budget for education programs and conferences you can attend
  • A working environment in which your contribution will make the difference


  • Sounds like a fit? Then we are looking forward to receiving your application via!
  • If you require any further information, feel free to contact Dr. Stephan Schaller on +49 151 58559070.

Get in touch now


esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 |