Meet us in Orlando!
From March 16th to 20th this year, ESQlabs will be at the Society of Toxicology’s 64th Annual Meeting – let’s connect!
If you are navigating chemical safety and regulatory challenges, we support data-driven risk assessment through advanced modeling—helping toxicologists, regulators, and industry to bridge the gap between in silico predictions and real-world decision-making.
Here’s a preview of what we’ll be sharing:
🔹 Unlocking the Power of PBK Modeling for Advanced Risk Assessment
PBK models are revolutionizing chemical safety assessments—but how do we make them more accessible?
Our CEO, Stephan, will lead a hands-on course on PBK modeling, covering physiological and chemical-specific parameters, population variability analysis, and high-throughput workflows for animal-to-human extrapolation. Using PK-Sim®, a component of the Open Systems Pharmacology Suite, we’ll explore age-dependent kinetics and quantitative Adverse Outcome Pathways to push risk assessment into the future.
About the presenter: Stephan Schaller is a Systems Scientist passionate about Model Based Drug Discovery, Development and Dosing (MI4D) with over eight years of industry experience. His experience ranges from target validation in the early phases of drug discovery to development of automated decision support systems for drug dosing at the point of care.
Read the abstract here: SOT25 Web App
🔹 The ExpoAdvance Roadmap: An EU Strategy on Aggregate Exposure
Chemical risk assessments mostly rely on single-source exposures, but real-world exposure comes from multiple sources. Our senior scientist Lara Lamon presents ExpoAdvance, the EFSA roadmap developed by international experts to advance multi-source exposure to a chemical. The roadmap outlines key challenges, priority research areas, and methodologies to improve aggregate exposure (AE) assessments across Europe. These projects lay the groundwork for future innovations in AE assessment, advancing predictive risk management and aligning with the Chemical Strategy for sustainability and the One Health approach for better public health protection and regulatory practice.
About the presenter: Lara Lamon is an Environmental Scientist with a solid drive to investigate the unknowns of chemical exposure and enhance model simulations to protect human health and the environment. She worked at ECVAM in JRC on the grouping and reading across nanomaterials. She provided a case study following the framework on read across released by ECHA for submissions of chemicals dossiers within the REACH regulation, and many other projects.
Read the abstract here: SOT25 Web App
🔹 Purrfect Fit: Validating the PK-Sim Cat Model for IV Administration
Did you know that cats are often treated as small dogs in veterinary medicine, despite major species-specific pharmacokinetic differences?
Our Scientist Leonie Lautz and the Head of Systems Toxicology and PBPK, Marco Siccardi, will present a new PBK model for cats by adapting a beagle dog model and testing it against real-world data from pharmaceuticals with varying half-lives.
The results? 100% of predicted plasma concentrations fell within a two-fold factor of measured data—a promising step for veterinary drug development and dose refinement.
About the presenter: Marco Siccardi is an expert in modeling and simulation, specializing in PBPK modeling, systems toxicology, and Next-Generation Risk Assessment (NGRA). He has led strategic initiatives and industry partnerships at Labcorp and ESQlabs and was an Associate Professor at the University of Liverpool. With over 130 peer-reviewed publications, he has contributed extensively to nanomedicine, infectious diseases, and risk assessment, bridging academia, industry, and regulatory science to drive innovation in MIDD and NGRA.
About the author: Leonie Lautz is a Scientist at esqLABS. Her work focuses on the development and application of harmonised methodologies applied to human health and animal health of chemicals, integration of cellular (in vitro) methods and computational models with a particular emphasis on kinetics and metabolism. Her research interests include physiologically based kinetic/dynamic modeling in livestock and laboratory animal species for next-generation risk assessment. She is involved in projects related to veterinary pharmaceuticals, contaminants, and feed/food safety.
Read the abstract: SOT25 Web App
🔹 Advancing Maternal-Fetal PBK Models for Cross-Species Risk Assessment
Pregnancy and lactation introduce unique physiological changes that influence drug and chemical exposure—but current models are often incomplete. Our Scientist, Sophie, presents newly developed maternal-fetal PBK models for both humans and rats, validated with real-world case studies. These models enable cross-species extrapolation, neurodevelopmental risk assessments, and improved regulatory safety evaluations for pregnant populations.
About the presenter: Sophie is a biophysicist interested in understanding the complex interactions driving physiological processes by using mathematical modeling and simulation. She supported project work with the development of popPK and PKPD models, to increase understanding of the exposure-effect relationship. She is passionate about female health-related topics and continued to promote her PhD work after graduation.
Read the abstract: SOT25 Web App
We Empower Chemical Risk Assessment
We generate quantitative exposure and toxicity evidence using innovative modeling approaches, enabling the reduction, refinement, and replacement of unnecessary in vivo experiments.
Our Risk Assessment and Systems Toxicology solutions encompass PBK simulations for risk assessment, quantitative systems toxicology for chemical evaluation, and toxicokinetics read across.
To learn more about our toxicology solutions, please contact info@esqlabs.com.
Contact
ESQlabs GmbH | Am Sportplatz 7 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com
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