Click to download the posters our scientists are presenting at PAGE:

• HT-PBK Framework in R Using OSP Software for Anti-Tuberculosis Drug Development. Download Here. 
• A PB-QSP Module for Ocular Applications for the Open Systems Pharmacology – A Vancomycin Example. Download Here. 
• Predicting Hormonal Contraceptives DDI by Leveraging the Model Database of the OSP Suite. Download Here. 
• Development of an End-to-End Quantitative Model-Informed Drug Development (MIDD) Ecosystem. Download Here. 
• Application of High-Throughput PBPK Modeling to Develop an IVIVE Approach for Oral Permeability. Download Here.
• Integration of a Novel First-Order Release Z-Factor Dissolution Model with Global Sensitivity Analysis to Guide Formulation Development using Physiologically-Based Biopharmaceutics in OSPSuite V12. Download Here. 
• Open-Source Quantitative Modeling of Tuberculosis Drug-Induced Cardiac Risks. Download Here. 
• Enhancing PB(P)K Models for the Female Reproductive Tract: A Framework for Local and Systemic Drug Kinetics. Download Here.
• Continuous infusion simulations in PBPK and QSP models reveal steady-state properties and rate-limiting steps. Download Here. 

Workshop Day 1: PBPK Modeling in OSP Suite V12 – Foundations and Special Populations

Physiologically-based pharmacokinetic (PBPK) modeling is a relevant approach to streamline drug development, providing a mechanistic framework to predict drug behaviour across different populations. With the latest developments in OSP Suite V12, PBPK modeling has become even more intuitive, efficient, and scalable. This hands-on workshop will guide participants through the basis of PBPK modeling using PK-Sim, with a special focus on paediatric, geriatric, and organ-impairment applications. 

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Workshop Day 2: Building Scalable PBPK-QSP Models – Modularization in MoBi for OSP Suite V12 

The latest OSP Suite V12 introduces a revolutionary modularization approach that significantly enhances the flexibility, scalability, and efficiency of quantitative systems pharmacology (QSP) modeling and integrations with physiologically-based PK (PBPK-QSP). This full-day hands-on workshop will equip participants with the skills to leverage modular workflows in MoBi to build, extend, and refine PBPK-QSP models like never before. Led by ESQlabs scientists, attendees will start with a simple two-compartment model to grasp the fundamentals of modularization before diving into a real-world case study: modeling an ADC modality for tumor treatment.

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Workshop Day 3: Modular PBPK Modeling and Quality-Controlled Simulation Workflows in R with OSP Suite V12 – Use Case: Pregnancy PBPK

This full-day workshop offers a powerful combination of hands-on modular customized PBPK(-QSP) modeling and quality-controlled simulation workflows in R, leveraging the latest advancements in OSP Suite V12. Participants will explore the new modularization framework in PK-Sim and MoBi, learning how to extend a PBPK model with a pregnancy module to simulate fetal drug exposure. The second half of the workshop focuses on streamlining PBPK-QSP modeling workflows in R using {esqlabsR}, a package designed to enhance reproducibility, transparency, and automation.

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