open position:

Senior Scientist QSP/T and PBP/TK (m/f/d)

Full Time, Starts May 1, 2020; Home Office based (EU-wide, with good connectivity to Frankfurt or Cologne, Germany)

Senior Scientist QSP/T and PBP/TK (m/f/d)

esqLABS has exciting projects for a highly talented and motivated life-science modeling & simulation scientist who enjoys driving innovations and setting new boundaries in physiologically-based (PBP/TK) modeling & quantitative systems toxicology or pharmacology (QSP/T).

esqLABS is not only an innovative contract research organization for the pharmaceutical, chemical, and food industry specialized in PBP/TK and QSP/T, but also a member of the Open-Systems-Pharmacology (OSP) Management Team. We help drive the development and standards of the open domain software (PK-Sim® and MoBi®) within a cross-functional environment with academia and industry to push the boundaries of quantitative systems pharmacology and systems toxicology. esqLABS has gained considerable momentum, providing world-wide services and attracting international players in the pharma and crop industry but also start-ups in the life-science technology sector as clients. In addition, funding through national and EU-wide research grants allows us to progressively further the development of our core technologies.

To help us grow and lead our global PBPK business, we are looking for a Senior Scientist QSP/T and PBP/TK (m/f/d) to strengthen our team.

About your new role

Are you a highly talented and motivated life-science modeling & simulation scientist? Do you enjoy driving innovation and setting new boundaries in physiologically-based (PBK) modeling & quantitative systems pharmacology and toxicology (QSP/T)? Then this could be a good fit:

  • Scientific Methodology & Strategy development
  • Project management for client projects in our PBPK and/or QST business
  • Assess and define regulatory requirements and compile submission-ready reports
  • Support customer projects (Hands-on PBK / QSP/T model development)
  • Track use cases and communicate with peers to assess project requirements
  • Challenge (project) requirements and engineer feasible solutions from start till end

Skills & experience we require

  • 5+ years of experience in applications of mechanistic modeling in toxicological risk assessment and/or pre-clinical and clinical development
  • 5+ years of experience in leading modeling & simulation projects for clients
  • Advanced expertise in domain-specific modeling software (e.g. R / PK-Sim® / MoBi®, SimCyp®, or GastroPlus®)
  • Advanced expertise in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)
  • Profound knowledge of the toxicological risk assessment and/or drug discovery and development process
  • Profound knowledge of regulatory requirements and guidelines for PBP/TK and TD
  • Fluency in English (oral and written)

Skills & experience that are nice to have

  • Advanced expertise in pharmacometric modeling software (e.g. NONMEM®, Monolix, or IQRtools)
  • A strong understanding of statistics
  • Therapeutic/Toxicology domain knowledge: Developmental Neurotoxicity, Hepatotoxicity (or DILI), Nephrotoxicity (and/or diseases such as Diabetes, Oncology, Immunology or Inflammation)
  • Experience in regulatory submissions
  • Published peer-reviewed articles

What we offer

  • A passionate and dedicated team with people who are always willing to broaden their horizon
  • Flexible work hours and a home office policy that focuses on people and not on numbers
  • An attractive remuneration package
  • A dedicated budget for education programs and conferences you can attend
  • A working environment in which your contribution will make the difference


  • Sounds like a fit? Then we are looking forward to receiving your application via!
  • If you require any further information, feel free to contact Dr. Stephan Schaller on +49 151 58559070.

Get in touch now


esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 |