ACoP 2024 Workshop 1 on Biologics (ADC) whole-body PBPK/QSP

November 10th, Arizona, USA

The development of large-molecule drugs has become increasingly complicated over the last decades due to the continuous addition of new modalities and mechanisms of action. The crucial role of biodistribution into multiple tissues for target binding, catabolism, and FcRn-mediated recycling throughout the body makes whole-body PBPK modeling an attractive option for model-informed drug development in this area. These models are especially useful if they can be extended to include target-mediated drug disposition (TMDD) in multiple organs where the target is expressed, and if pharmacodynamic elements can be added to obtain integrated PBPK-QSP models.


ESQlabs will provide hands-on training on the development of these models using PK-Sim® and MoBi® (OSP-Suite). The workshop will cover general introductions to applying this freely available open-source software suite and will provide state-of-the-art example models and development workflows. In-depth exercises will cover PBPK and PD modeling for monoclonal antibodies, antibody-drug-conjugates (ADCs) for tumor growth inhibition, FcRn inhibitors, and bispecific immune cell engagers.

While the workshop does not require prior experience with PK-Sim® and MoBi®, many topics will interest even advanced users.

Workshop Instructors:

  • Dr. Alexander Kulesza (Lead Systems Pharmacology)
  • Dr. Wilbert De Witte (Principal Scientist)

Date: Sunday, 10th November 2024

Time: 09:00 – 17:00

Location: It will be the conference hotel. More details will be provided closer to the date.

Fee: 750 USD (+tax) for the ACoP members, 950 USD (+tax) for non-members, and 450 USD (+tax) for students. The fee includes coffee breaks and lunch for both days.

Registration: Go to the ACoP registration portal.

For any further support, do not hesitate to contact us via email.

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ESQlabs GmbH | Am Sportplatz 7 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 |

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