PAGE 2024 Workshop 1 on ADC & Small Molecule DDI

June 24th, Rome, Italy

esqLABS will provide hands-on training on the most sought-after topics in physiologically-based pharmacokinetic (PBPK) and quantitative systems pharmacology (QSP) modeling using PK-Sim® and MoBi® (OSP-Suite). The first workshop will cover practices for protein/antibody PBPK and PD modeling for antibody-drug-conjugates (ADCs) for the treatment of tumor growth accounting for target-mediated drug disposition (TMDD). In the afternoon, it will provide in-depth training on how to leverage the OSP-Suite Software and Model Library for PBPK-based assessments of drug-drug interactions (DDI).


Learning objectives:

Develop, extend, and customize PBPK models with a focus on biologics to simulate disease mechanisms and drug effects (PBPK/PD or PBPK-QSP models) using PK-Sim® and MoBi®.

  • Gain experience with hands-on exercises with a protein/antibody PBPK model for ADCs for the treatment of tumor growth accounting for TMDD

Explore how to simulate the PK of a drug and its metabolite and the metabolizing enzyme for DDI.

    • Learn how to work with the OSP Suite Model Template Database
    • Learn how to define Parent-Metabolite and Drug-Interaction kinetics
    • Learn about regulatory requirements for the execution and reporting of PBPK-based DDI assessments

While the workshop does not require prior experience with PK-Sim® and MoBi®, many topics will interest even advanced users.

Workshop Instructors:

  • Dr. Stephan Schaller (CEO and Lead Scientist)
  • Pavel Balazki (Software Lead)
  • Dr. Wilbert De Witte (Principal Scientist)

Date: Monday, 24th June 2024

Time: 09:00 – 17:00

Location: It will either be the conference hotel or a hotel in its vicinity.

Fee: 500 EUR (+tax) for industry, 300 EUR (+tax) for academia & non-profit, and 150 EUR (+tax) for students.

The fee includes coffee breaks and lunch for both days.

For more details and information on how to register, please visit our webshop or contact us via email.

The registered participants will be given a free voucher to access our upcoming course on OSP R & esqlabsR frameworks!

Get in touch now


ESQlabs GmbH | Am Sportplatz 7 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 |

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