Dr. Huan Yang joins esqLABS

From April 1, 2021, on Dr. Huan Yang, a trained Applied Mathematician and Systems Toxicology Modeller from Leiden University will be reinforcing esqLABS.



Dr. Huan Yang joins esqLABS

Dr. Huan Yang is a mathematical modeler, who is passionate about computational modeling, data analysis, and machine learning for life-science innovation. Before joining esqLABS, Huan has applied systems modeling to tackle problems in pharmacology/toxicology, neuroscience, and psychology.

His PhD research at the University of Twente (2011-2015) focused on computational modeling of nociceptive systems with human-subject perception data. He developed and applied system identification and parameter estimation technique to recover neurophysiological parameters, leading to a mechanistic diagnosis of peripheral and central neuronal subsystems underlying the development of chronic pain. In 2016, he started his postdoc at the LACDR of Leiden University. He developed quantitative systems approaches to gain insights into how biological systems (ranging from in-vitro PK to signaling pathways) respond to chemical/drug exposure.

Towards predictive toxicology, his modeling work incorporated various types of data from high-content microscopy imaging, sequencing, and mass spectrometry generated by academic and industrial collaborators. These mathematical models also quantitatively characterized several key events and their relationship in AOPs for the next generation risk assessment. Currently, he is also a visiting researcher at Leiden University.

Peer Reviewed Journal Articles:

  1. Yang H., van der Stel W., Lee R., Walker P., Bevan S., Bauch C., van de Water B., Danen E.H., & Beltman J.B. (2021), Dynamic modeling of mitochondrial membrane potential upon exposure to mitochondrial inhibitors, under review.
    Yang H., Niemeijer M.,van de Water B., & Beltman J.B. (2020), ATF6 is a critical determinant of CHOP dynamics during the unfolded protein response, iScience 23(2): 100860.
    Zgheib E., Gao W., Limonciel A., Aladjov G., Yang H., Tebby C., Gayraud G., Jennings P., Sachana M., Beltman J.B. & Bois F.Y. (2019), Application of three approaches for quantitative AOP development to renal toxicity, Computational Toxicology 11: 1-13.
    Kuijper I.A., Yang H., van de Water B., Beltman J.B. (2017), Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling, Expert opinion on drug metabolism & toxicology 13 (1), 5-17.
    Yang H., Meijer H.G.E., Buitenweg J.R., & van Gils S.A. (2016), Estimation and identifiability of model parameters in human nociceptive processing using stimulus-response pairs, Frontiers in psychology 7, 1884.
    Yang H., Meijer H.G.E., Doll R.J., Buitenweg J.R., & van Gils S.A. (2015), Dependence of nociceptive detection thresholds on physiological parameters and capsaicin-induced neuroplasticity: a computational study, Frontiers in computational neuroscience 10, 49.
    Yang H., Meijer H.G.E., Doll R.J., Buitenweg, J.R., & van Gils S.A. (2015), Computational modeling of Adelta-fiber-mediated nociceptive detection of electrocutaneous stimulation, Biological Cybernetics, Vol. 149, No. 4, Page 479-491.
    Lähnemann D., Köster J.,…Yang H.,…, Schönhuthm A. (2020), Eleven grand challenges in single-cell data science. Genome Biology 21, 1–35.
    Punt A., Bouwmeester H.,…,Yang H., …, MB Heringa (2020), New approach methodologies (NAMs) for human-relevant biokinetics predictions: meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment. Altex. 37(4), 607-622.
    Yang H., Buitenweg J.R., & Meijer H.G.E., (2012) Identification of the nociceptive forward pathway using perception thresholds, IFAC Proceedings Volumes, 45(18), 367-372.


Conference Talks:

  1. Yang H., Niemeijer M., van de Water B., Beltman J.B., Integration of computational modelling and high-content imaging to understand chemical-induced unfolded protein response, MGC Symposium, Leiden, the Netherlands, September 2018.

  2. Yang H., Niemeijer M., van de Water B., Beltman J.B., Computational modeling of the unfolded protein response pathway and its role in cellular injuries, Computational Hub meeting Leiden, the Netherlands, June 2018.

  3. Yang H., Meijer H.G.E., Doll R.J., Buitenweg J.R., & van Gils S.A., Capsaicin-induced neuroplasticity on human nociceptive function: a model-based study, 5th Dutch Bio-Medical Engineering Conference, Egmond aan Zee, the Netherlands, Jan 2015.

  4. Yang H., Buitenweg J.R., & Meijer H.G.E., System identification of the nociceptive function, 29th Annual Meeting of the International Society for Psychophysics, Freiburg im Breisgau, Germany, October 2013.

  5. Yang H., Buitenweg J.R., & Meijer H.G.E., Identification of the nociceptive forward pathway using perception thresholds, 8th International Federation of Automatic Control (IFAC) Symposium on Biological and Medical Systems, Budapest Hungary, August 2012.


Get in touch now


esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com