pre/post PAGE 2020 OSP-Suite Workshops

two hands-on PK-Sim® & MoBi® workshops on PBPK and PBPK-based QSP on Tuesday and Saturday 9th and 13th of June 2020 as satellite meetings to the PAGE Meeting 2020 in Ljubljana, Slovenia

PK-Sim® & MoBi® workshops on PBPK and PBPK-based QSP

esqLABS is running two hands-on PK-Sim® & MoBi® workshops on PBPK and PBPK-based QSP on Tuesday and Saturday 9th and 13th of June 2020 as (pre & post) satellite meetings to the PAGE Meeting 2020 in Ljubljana, Slovenia.

The workshops cover the basics of PBPK, qualification of PBPK for regulatory purpose, PBPK for DDI and pediatrics and the extension of PBPK with customized organ physiology and pharmacodynamics. The two workshops will enable participants to use PK-Sim® & MoBi® for PBPK in a regulatory setting (Day 1) and to build their very own PBPK-QSP platforms for the quantitative prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic (Day 2).

Within the two workshops, you will learn how to:

Workshop 1 / Day 1:

  • Qualify PBPK models for intended use using the PK-Sim® qualification framework,
  • Learn how to model drug-drug interactions in PK-Sim (DDI)
  • Learn how to consider age-dependency in drug PK in PK-Sim (Pediatric Analyses)
  • Assess variability within population simulations

Workshop 2 / Day 2:

  • Integrate PBPK with mechanism-based pharmacodynamics in MoBi
  • Extend the PBPK physiology with customized organs in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  • Run, plot, and analyze your PBPK-QSP models in R

The two workshops will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.

LOCATION

Workshop 1 PBPK (June 9, 2020)

To be announced (near the PAGE Meeting)

Workshop 2 PB-QSP (June 13, 2020)

To be announced (near the PAGE Meeting)

REGISTRATION

You can register for each workshop separately or for both days at a reduced price.

Each workshop day is currently restricted to 15 participants.

Registration includes coffee- and lunch breaks.

AGENDA

The use-cases within the workshops will be based on published examples.

We will develop PBPK models for small molecules for DDI and pediatric populations and PBPK models for biologics (antibody-drug conjugates (ADCs)), which we develop into a PB-QSP model for treatment of tumor growth.

The two workshop days are scheduled as follows:

Day 1 (9th June, 2020)

Agenda Day 1

Day 2 (13th June, 2020)

Agenda Day 2

PREPARATION

  • BRING YOUR OWN LAPTOPS, pre-installed with the software! We will be doing hands-on work!
  • To download the software, please click here
  • Download & install the R distribution (Ver 3.5+) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here

NOTES

  • Please add this site to your watchlist (very top of page) to be informed of any changes.

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.

 

Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

Get in touch now

Contact

esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com