pre-ASCPT OSP-Suite Workshops
two hands-on PK-Sim® & MoBi® workshops on PBPK and PBPK-based QSP on Monday and Tuesday 16th and 17th of March 2020 (pre ASCPT) at the University of Houston
PK-Sim® & MoBi® workshops on PBPK and PBPK-based QSP
esqLABS, in collaboration with the University of Houston, College of Pharmacy, is running two hands-on PK-Sim® & MoBi® workshops on PBPK and PBPK-based QSP on Monday and Tuesday 16th and 17th of March 2020 (pre ASCPT) at the University of Houston
The workshops cover the basics of PBPK and concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic.
Within the two workshops, you will learn how to:
Workshop 1 / Day 1:
- Build a PBPK model in PK-Sim and compare to observed data
- Learn how to model drug-drug interactions in PK-Sim (DDI)
- Learn how to consider age-dependency in drug PK in PK-Sim (Pediatric Analyses)
- Conduct population simulations in PK-Sim and MoBi
Workshop 2 /Day 2:
- Integrate mechanism-based PD in PK-Sim & MoBi
- Conduct parameter identifications in PK-Sim & MoBi
- Simulate and analyze your PBPK-QSP model in RStudio
The two workshops will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.
While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.
Just a 10-min ride from the ASCPT2020 conference hotel (Marriot Marquis):
Department of Pharmacological and Pharmaceutical Sciences
College of Pharmacy, University of Houston
Health Building (HB) 2, Room 3001
4849 Calhoun Rd
Houston, TX 77204-5037
You can register for each workshop separately or for both at a reduced price.
You can Register on Eventbrite:
Each workshop day is currently restricted to 15 external participants.
Registration includes coffee- and lunch breaks.
The use-cases within the workshops will be based on published examples.
We will develop PBPK models for small molecules for DDI and pediatric populations and PBPK models for biologics (antibody-drug conjugates (AsDC)), which we develop into a PB-QSP model for treatment of tumor growth.
The two workshop days are scheduled as follows:
- BRING YOUR OWN LAPTOPS, pre-installed with the software! We will be doing hands-on work!
- To download the software, please click here
- Download & install the R distribution (Ver 3.5+) from here
- Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
- For starters, please check out the tutorial site (videos & hands-on) here
- Please add this site to your watchlist (very top of page) to be informed of any changes.
Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.
(Managing Director, esqLABS GmbH)