Boston PBPK/PD Workshop September 2019

esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on PBPK/PD of Small Molecules and Antibodies on Thursday 19th of September 2019 at the Workbar (Big Bang Room), 45 Prospect St, Cambridge, MA 02139.

PK-Sim® & MoBi® (OSP Suite) workshop on PBPK/PD of Small Molecules and Antibodies

esqLABS is running an advanced one-day hands-on PK-Sim® & MoBi® workshop on PPBPK/PD of Small Molecules and Antibodies on Thursday 19th of September at the Workbar (Big Bang Room), 45 Prospect St, Cambridge, MA 02139, USA follwing the Boston QSP Meeting. The workshop covers concepts and application of combining PK-Sim, MoBi and R for translational research and clinical development by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build small molecule and antibody/protein PBPK models in PK-Sim and compare to observed data
  • Learn how to model drug-drug interactions in PK-Sim (DDI)
  • Extend/adapt the physiology of your PBPK model in MoBi
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  • Simulate and analyze your PBPK-QSP model in R

This workshop will be held by consultants & scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.


To register for the workshop, please visit EventBrite.

The workshop is currently restricted to 15 participants.

Registration includes coffee- and lunch breaks.


As use-cases for above learnings, we will

  • model and simulate drug-drug interactions with midazolam and itraconazoile
  • build a PBPK/PD model for use of antibody-drug conjugate (ADC) in tumor treatment in detail:
Time (Thursday September 19) Topic
9:00 Welcome and getting everyone started
9:15 Lecture: Introduction to PK-Sim® & MoBi®
9:45 Hands-On: Building small molecule and mAb/ADC PBPK models in PK-Sim®
10:15 Lecture: Parameter Identification using PK-Sim® and Mobi®
10:30 Coffee Break
10:45 Hands-On: Parameter Identification
11:15 Lecture: PBPK concepts: Drug-drug interactions (DDI) with PK-Sim®
11:45 Hands-On: Modeling drug-drug interactions (DDI) with PK-Sim®
12:30 Lunch Break
13:30 Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition
14:00 Hands-On: Tumor growth and tumor treatment modeling
15:15 Coffee Break
15:30 Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R
16:30 Wrap-up and Q & A
17:00 END


BRING YOUR OWN LAPTOPS! We will be doing hands-on work!

  • To download the software (WINDOWS ONLY!), please click here
  • Download & install the R distribution (Ver 3.5+; 64 Bit) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here


  • Please add this site to your watchlist (very top of page) to be informed of any changes.

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.


Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

Get in touch now


esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 |