PB-QSP Workshop @ PAGE 2019
esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions on Saturday 15th of June at the Freys Hotel in Stockholm, Sweden as a satellite meeting to PAGE 2019.
PK-Sim® & MoBi® (OSP Suite) workshop on PBPK-based QSP
esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on integrating PBPK with QSP for in-silico first-in-man PD predictions on Saturday 15th of June at the Freys Hotel in Stockholm, Sweden as a satellite meeting to PAGE 2019. The workshop covers concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:
- Build a PBPK model in PK-Sim and compare to observed data
- Integrate mechanism-based pharmacodynamics in MoBi
- Conduct parameter identifications in PK-Sim and MoBi
- Simulate and analyze your PBPK-QSP model in R
This workshop will be held by consultants & scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.
While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.
REGISTRATION
To register for the workshop, please visit EventBrite.
The workshop is currently restricted to 20 participants.
Registration includes coffee- and lunch breaks.
AGENDA
As a use-case for above learnings, we will develop a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:
| Time (Saturday June 15) | Topic |
|---|---|
| 9:00 | Welcome and getting everyone started |
| 9:15 | Lecture: Introduction to MoBi® |
| 9:30 | Hands-On: Building an ADC PBPK model |
| 10:00 | Coffee Break |
| 10:15 | Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition |
| 11:15 | Hands-On: Tumor growth modeling |
| 12:00 | Lunch Break |
| 13:00 | Lecture: Parameter Identification using PK-Sim® and Mobi® |
| 13:30 | Hands-On: Parameter Identification |
| 14:00 | Coffee Break |
| 14:15 | Hands-On: nAb / ADC tumor treatment (PD-Effect) |
| 15:45 | Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R |
| 16:30 | Wrap-up and Q & A |
| 17:00 | END |
PREPARATION
BRING YOUR OWN LAPTOPS! We will be doing hands-on work!
- To download the software, please click here
- Download & install the R distribution (Ver 3.5+) from here
- Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
- For starters, please check out the tutorial site (videos & hands-on) here
NOTES
Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.
Best Regards,
Stephan Schaller
(Managing Director, esqLABS GmbH)
Get in touch now
Contact
esqLABS GmbH | Hambierich 34 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com
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