2-Day OSP Suite Workshop

esqLABS is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 9th and 10th of March 2019 (pre ASCPT) at the University of Florida Orlando, FL (Lake Nona Campus).

PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP

esqLABS, in collaboration with the University of Florida, is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 9th and 10th of March 2019 (pre ASCPT) at the UF Research and Academic Center at Lake Nona (6500 Sanger Rd, Orlando, FL 32827, USA). The workshop covers the basics of PBPK and concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a PBPK model in PK-Sim and compare to observed data
  • Learn how to consider age-dependency in drug PK in PK-Sim (Pediatrics and Geriatrics)
  •  Conduct population simulations in PK-Sim and MoBi
  • Learn how to model oral drug absorption in PK-Sim (IVIVE, Bioavailability)
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  •  Simulate and analyze your PB-QSP model in R

This workshop will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, most topics will be of interest even for advanced users.


To register for the workshop, please visit EventBrite.

The workshop is currently restricted to 15 participants.

Registration includes coffee- and lunch breaks.


As use-cases for above learnings, we will develop PBPK models for small molecules and biologics and a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Day 1

Time (Saturday March 9) Topic
9:00 Welcome and getting everyone started (solving IT issues)
9:30 Lecture: Introduction to PBPK modeling and the OSP Suite (PK-Sim® & MoBi®)
10:00 Hands-On: Setting up a simple PBPK model
10:45 Coffee Break
11:00 Lecture: General concepts of PBPK modeling
11:30 Lecture: PBPK for oral absorption with PK-Sim®
12:00 Lunch Break
13:00 Hands-On: Modeling oral absorption with PK-Sim®
14:45 Lecture: Special populations – pediatrics and elderly
15:15 Coffee Break
15:30 Hands-On: Age Dependence of Pharmacokinetics (Population Simulations)
16:30 Wrap-up and Q & A
17:00 END

Day 2

Time (Sunday March 10) Topic
9:00 Welcome and getting everyone started (follow-up Day 1)
9:15 Lecture: Introduction to MoBi®
9:30 Hands-On: Building an ADC PBPK model
10:00 Coffee Break
10:15 Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition
11:15 Hands-On: Tumor growth modeling
12:00 Lunch Break
13:00 Lecture: Parameter Identification using PK-Sim® and Mobi®
13:30 Hands-On: Parameter Identification
14:00 Coffee Break
14:15 Hands-On: nAb / ADC tumor treatment (PD-Effect)
15:45 Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R
16:30 Wrap-up and Q & A
17:00 END


  • To download the software, please click here
  • Download & install the R distribution (Ver 3.5) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the OSP tutorial site (videos & hands-on) here

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.

Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

Get in touch now


ESQlabs GmbH | Am Sportplatz 7 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com

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