2-Day OSP Suite Workshop
esqLABS is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland in Baltimore, MD.
PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP
esqLABS, in collaboration with the University of Maryland, is running a two-day hands-on PK-Sim® & MoBi® workshop on PBPK and PBPK-based QSP on Saturday and Sunday 16th and 17th of March 2019 (post ASCPT) at the University of Maryland (Pharmacy Hall, 20 N Pine St, Baltimore, MD 21201). The workshop covers the basics of PBPK and concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:
- Build a PBPK model in PK-Sim and compare to observed data
- Learn how to consider age-dependency in drug PK in PK-Sim (Pediatrics and Geriatrics)
- Conduct population simulations in PK-Sim and MoBi
- Learn how to model drug-drug interactions in PK-Sim (DDI)
- Integrate mechanism-based pharmacodynamics in MoBi
- Conduct parameter identifications in PK-Sim and MoBi
- Simulate and analyze your PB-QSP model in R
This workshop will be held by the consultants and scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.
While the workshop does not require any prior experience with PK-Sim® & MoBi®, most topics will be of interest even for advanced users.
REGISTRATION
To register for the workshop, please visit EventBrite.
The workshop is currently restricted to 15 participants.
Registration includes coffee- and lunch breaks.
AGENDA
As use-cases for above learnings, we will develop PBPK models for small molecules and biologics and a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:
Day 1
Time (Saturday March 16) | Topic |
---|---|
9:00 | Welcome and getting everyone started (solving IT issues) |
9:30 | Lecture: Introduction to PBPK modeling and the OSP Suite (PK-Sim® & MoBi®) |
10:00 | Hands-On: Setting up a simple PBPK model |
10:45 | Coffee Break |
11:00 | Lecture: General concepts of PBPK modeling |
11:30 | Lecture: PBPK for drug-drug interactions (DDI) with PK-Sim® |
12:00 | Lunch Break |
13:00 | Hands-On: Modeling drug-drug interactions (DDI) with PK-Sim® |
14:45 | Lecture: Special populations – pediatrics and elderly |
15:15 | Coffee Break |
15:30 | Hands-On: Age Dependence of Pharmacokinetics (Population Simulations) |
16:30 | Wrap-up and Q & A |
17:00 | END |
Day 2
Time (Sunday March 17) | Topic |
---|---|
9:00 | Welcome and getting everyone started (follow-up Day 1) |
9:15 | Lecture: Introduction to MoBi® |
9:30 | Hands-On: Building an ADC PBPK model |
10:00 | Coffee Break |
10:15 | Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition |
11:15 | Hands-On: Tumor growth modeling |
12:00 | Lunch Break |
13:00 | Lecture: Parameter Identification using PK-Sim® and Mobi® |
13:30 | Hands-On: Parameter Identification |
14:00 | Coffee Break |
14:15 | Hands-On: nAb / ADC tumor treatment (PD-Effect) |
15:45 | Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R |
16:30 | Wrap-up and Q & A |
17:00 | END |
PREPARATION
- To download the software, please click here
- Download & install the R distribution (Ver 3.5) from here
- Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
- For starters, please check out the OSP tutorial site (videos & hands-on) here
Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.
Best Regards,
Stephan Schaller
(Managing Director, esqLABS GmbH)
Get in touch now
Contact
ESQlabs GmbH | Am Sportplatz 7 | 26683 Saterland | Germany
Tel. +49 151 / 58559070 | info@esqLABS.com
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